Manchester United and Tottenham are paired after finishing the league phase in third and fourth, meaning they will be on different sides of the draw.
It also meant that both Premier League clubs will have had a keen eye on the same play-off matches last night.
In those ties, AZ Alkmaar beat Galatasaray 6-3 on aggregate, while Real Sociedad knocked out Midtjylland by a 7-3 aggregate scoreline.
AZ are on the left side of the bracket with fellow play-off winners Viktoria Plzen, Bodo/Glimt and Ajax.
La Real are on the right with AS Roma, Fenerbahce and FCSB.
Content Source: www.express.co.uk